ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models

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	ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models
	Yue, W; Li, YY; Zhang, T; Jiang, M; Qian, Y; Zhang, M; Sheng, NY; Feng, S; Tang, K; Yu, X
刊名	STEM CELL REPORTS
	2015
卷号	5 期号:5 页码:776-790
关键词	EMBRYONIC STEM-CELLS SONIC HEDGEHOG PARKINSONS-DISEASE TRANSGENIC MICE MEMORY DEFICITS AMYLOID-BETA TRANSPLANTATION DISORDERS BRAIN RATS
通讯作者	Yue, CM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,cmyue@sibcb.ac.cn ; njing@sibcb.ac.cn
英文摘要	Degeneration of basal forebrain cholinergic neurons (BFCNs) is associated with cognitive impairments of Alzheimer's disease (AD), implying that BFCNs hold potentials in exploring stem cell-based replacement therapy for AD. However, studies on derivation of BFCNs from embryonic stem cells (ESCs) are limited, and the application of ESC-derived BFCNs remains to be determined. Here, we report on differentiation approaches for directing both mouse and human ESCs into mature BFCNs. These ESC-derived BFCNs exhibit features similar to those of their in vivo counterparts and acquire appropriate functional properties. After transplantation into the basal forebrain of AD model mice, ESC-derived BFCN progenitors predominantly differentiate into mature cholinergic neurons that functionally integrate into the endogenous basal forebrain cholinergic projection system. The AD mice grafted with mouse or human BFCNs exhibit improvements in learning and memory performances. Our findings suggest a promising perspective of ESC-derived BFCNs in the development of stem cell-based therapies for treatment of AD.
学科主题	Cell & Tissue Engineering; Cell Biology
WOS标题词	Cell Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000364991000010
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3925]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yue, W,Li, YY,Zhang, T,et al. ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models[J]. STEM CELL REPORTS,2015,5(5):776-790.
APA	Yue, W.,Li, YY.,Zhang, T.,Jiang, M.,Qian, Y.,...&Jing, NH.(2015).ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models.STEM CELL REPORTS,5(5),776-790.
MLA	Yue, W,et al."ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models".STEM CELL REPORTS 5.5(2015):776-790.