近年来,基于联合用药策略的双药物控释体系的研究为降低抗癌药物毒性和提高疗效提供了有效途径。水凝胶作为一类高临床应用价值的药物载体,在药物控释方面具有广泛的应用前景。癌症是危害人类健康和生命的疾病之一,当人体内正常细胞发生癌变后,癌变细胞周围会发生一些显著的变化。因此,根据肿瘤细胞与正常细胞在体内环境及体外环境的差异,发展了多种智能型水凝胶双抗癌药物控释载体。它能够在感知外界因素的刺激下发生内部结构的变化,从而实现对药物的可控释放。与此同时,随着新的治疗手段的兴起和更多抗癌作用靶点的发现,水凝胶载体也成功实现了化学药物和生物治疗因子的同时负载和可控释放。本文将从不同智能型水凝胶载体如何负载、控释双抗癌药物及水凝胶药物载体中药物的组合方式两方面综述智能型水凝胶双抗癌药物控释体系最新研究进展,并展望其发展前景。

In recent years, the development of codelivery systems based on combination strategies has provided an effective approach for reducing side effect and retaining drug bioactivity of anti-cancer drugs. Cancer is one of the most serious diseases endangering human health. There are some significant changes between normal tissues and cancerous tissues, and such changes have motivated researchers to design multiple intelligent hydrogel-based dual drug carriers for drug controlled release. Meanwhile, with the development of effective treatment, modulating multiple targets simultaneously can be achieved through a combination of anticancer drug and biological factor in hydrogel. The dual-drug controlled release from hydrogel is also realized. In the review, the recent advance on the intelligent hydrogel-based dual drug delivery system are summarized, which are classified referring to the mechanism of hydrogel loaded dual drugs, the release principles of drugs and the means of combination of drugs. In addition, some personal perspectives on this field are also presented.