Asymmetric total synthesis of (S)-isocorydine

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Asymmetric total synthesis of (S)-isocorydine
	Zhong, Mei 1,2,3; Jiang, Yunbin 4; Chen, Yali 5; Yan, Qian1,2,3 ; Liu JX(柳军玺)1,2 ; Di DL(邸多隆)1,2 ; Liu JX(柳军玺)
刊名	Tetrahedron: Asymmetry
	2015
卷号	26 期号:20 页码:1145-1149
ISSN号	0957-4166
通讯作者	柳军玺
英文摘要	The asymmetric total synthesis of (S)-isocorydine, a potential drug for the cure of hepatocellular carcinoma, is described. Asymmetric transfer hydrogenation of 3,4-dihydroisoquinoline using a chiral Ru(II) catalyst was applied to the synthesis of isocorydine as the key step, in which the ee value achieved is up to 99%. The overall yield is 9.4% after 12 synthetic procedures.
学科主题	分析化学与药物化学
收录类别	SCI
资助信息	‘West Light Program’, of the Chinese Academy of Sciences (090NKCA127);the Science and Technology Program of Gansu (1304FKCA062)
语种	英语
WOS记录号	WOS:000363908100005
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/19066]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
通讯作者	Liu JX(柳军玺)
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 4.Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China 5.Lanzhou Univ, Sch Basic Med Sci, Gansu Key Lab Preclin Study New Drugs, Inst Pharmacol, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhong, Mei,Jiang, Yunbin,Chen, Yali,et al. Asymmetric total synthesis of (S)-isocorydine[J]. Tetrahedron: Asymmetry,2015,26(20):1145-1149.
APA	Zhong, Mei.,Jiang, Yunbin.,Chen, Yali.,Yan, Qian.,Liu JX.,...&柳军玺.(2015).Asymmetric total synthesis of (S)-isocorydine.Tetrahedron: Asymmetry,26(20),1145-1149.
MLA	Zhong, Mei,et al."Asymmetric total synthesis of (S)-isocorydine".Tetrahedron: Asymmetry 26.20(2015):1145-1149.