Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives

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	Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives
	Wu, Chongyang 1; Li, Guofeng 1; Sun, Wangsheng 1; Zhang, Ming 1; Hong, Liang 1; Wang R(王锐)1,2
刊名	Organic Letters
	2014
卷号	16 期号:7 页码:1960-1963
ISSN号	1523-7060
英文摘要	A new practical organocatalytic asymmetric protocol for the introduction of a monofluoroalkyl group into the oxindole framework has been successfully developed. Excellent diastereoselectivities (>20:1 dr) and enantioselectivities (93-99% cc) of the products were obtained with a wide range of pre-electrophiles (3-bromooxindoles) and prenucleophiles (alpha-fluorinated beta-keto gem-diols). The obtained products themselves and their derivatives may significantly benefit drug discovery.
学科主题	物理化学与绿色催化
收录类别	SCI
资助信息	the NSFC (91213302;21272102;21202071);the Fundamental Research Funds for the Central Universities (lzujbky-2013-ct06;lzujbky-2013-77)
语种	英语
WOS记录号	WOS:000334016600033
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/19254]
专题	兰州化学物理研究所_OSSO国家重点实验室
作者单位	1.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Wu, Chongyang,Li, Guofeng,Sun, Wangsheng,et al. Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives[J]. Organic Letters,2014,16(7):1960-1963.
APA	Wu, Chongyang,Li, Guofeng,Sun, Wangsheng,Zhang, Ming,Hong, Liang,&Wang R.(2014).Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives.Organic Letters,16(7),1960-1963.
MLA	Wu, Chongyang,et al."Organocatalytic Highly Enantioselective Monofluoroalkylation of 3-Bromooxindoles: Construction of Fluorinated 3,3 '-Disubstituted Oxindoles and Their Derivatives".Organic Letters 16.7(2014):1960-1963.