Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization
	Zhou, Min; Li, Xing-Ren; Tang, Jian-Wei; Liu, Yang; Li, Xiao-Nian; Wu, Bin; Qin, Hong-Bo; Du, Xue; Li, Li-Mei; Wang, Wei-Guang
刊名	ORGANIC LETTERS
	2015-12-18
卷号	17 期号:24 页码:6062-6065
英文摘要	Scopariusicides A (1) and B (2), two novel immunosuppressive unsymmetrical cyclobutane derivatives, were isolated from the aerial parts of Isodon scoparius. Moreover, based on the results of phytochemical investigation, a concise stereocontrolled synthesis of scopariusicide A and its analogues with enhanced biological activities was efficiently achieved using the main diterpenoid (3) isolated from this plant as a readily available starting material. A crossed intermolecular [2 + 2] photocycloaddition and a Pd-catalyzed sp3 C-H bond beta-arylation were used synergistically to access the highly congested unsymmetrical cyclobutane core with four contiguous stereocenters.
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	ORGANIC-SYNTHESIS ; ISODON-SCOPARIUS ; ARYLATION ; PIPERARBORENINES ; ACTIVATION ; REVISION ; BONDS
收录类别	SCI
语种	英语
WOS记录号	WOS:000366878300032
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25330]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhou, Min,Li, Xing-Ren,Tang, Jian-Wei,et al. Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization[J]. ORGANIC LETTERS,2015,17(24):6062-6065.
APA	Zhou, Min.,Li, Xing-Ren.,Tang, Jian-Wei.,Liu, Yang.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2015).Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization.ORGANIC LETTERS,17(24),6062-6065.
MLA	Zhou, Min,et al."Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization".ORGANIC LETTERS 17.24(2015):6062-6065.