Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats
	Naito,Yukiko; Ji,Xu; Tachibana,Shigehiro; Aoki,Satoko; Furuya,Mami; Tazura,Yoshiyuki; Miyazawa,Daisuke; Harauma,Akiko; Moriguchi,Toru; Nagata,Tomoko
刊名	BRITISH JOURNAL OF NUTRITION
	2015-09-14
卷号	114 期号:5 页码:734-745
关键词	Arachidonic acid Colitis Dextran sodium sulphate Supplementation
英文摘要	The aim of this study was to investigate the effects of the administration of oral arachidonic acid (AA) in rats with or without dextran sulphate sodium (DSS)-induced inflammatory bowel disease. Male Wistar rats were administered AA at 0, 5, 35 or 240 mg/kg daily by gavage for 8 weeks. Inflammatory bowel disease was induced by replacing drinking water with 3 % DSS solution during the last 7 d of the AA dosing period. These animals passed loose stools, diarrhoea and red-stained faeces. Cyclo-oxygenase-2 concentration and myeloperoxidase activity in the colonic tissue were significantly increased in the animals given AA at 240 mg/kg compared with the animals given AA at 0 mg/kg. Thromboxane B-2 concentration in the medium of cultured colonic mucosae isolated from these groups was found to be dose-dependently increased by AA, and the increase was significant at 35 and 240 mg/kg. Leukotriene B-4 concentration was also significantly increased and saturated at 5 mg/kg. In addition, AA at 240 mg/kg promoted DSS-induced colonic mucosal oedema with macrophage infiltration. In contrast, administration of AA for 8 weeks, even at 240 mg/kg, showed no effects on the normal rats. These results suggest that in rats with bowel disease AA metabolism is affected by oral AA, even at 5 mg/kg per d, and that excessive AA may aggravate inflammation, whereas AA shows no effects in rats without inflammatory bowel disease.
类目[WOS]	Nutrition & Dietetics
研究领域[WOS]	Nutrition & Dietetics
关键词[WOS]	POLYUNSATURATED FATTY-ACIDS ; BOWEL-DISEASE ; DIETARY SUPPLEMENTATION ; MURINE COLITIS ; EXPRESSION ; PHOSPHOLIPIDS ; MUCOSA ; BRAIN ; MODEL ; N-3
收录类别	SCI
语种	英语
WOS记录号	WOS:000360579900009
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25115]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Naito,Yukiko,Ji,Xu,Tachibana,Shigehiro,et al. Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats[J]. BRITISH JOURNAL OF NUTRITION,2015,114(5):734-745.
APA	Naito,Yukiko.,Ji,Xu.,Tachibana,Shigehiro.,Aoki,Satoko.,Furuya,Mami.,...&Ohara,Naoki.(2015).Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats.BRITISH JOURNAL OF NUTRITION,114(5),734-745.
MLA	Naito,Yukiko,et al."Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats".BRITISH JOURNAL OF NUTRITION 114.5(2015):734-745.