Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice

	Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice
	Yin, Li ; Wei, Lei ; Fu, Rao ; Ding, Lisheng ; Guo, Yiran ; Tang, Lin ; Chen, Fang
刊名	MOLECULES
	2014
卷号	19 期号:6 页码:7223-7236
关键词	Veronica ciliata Fisch antioxidant activity hepatoprotective effect carbon tetrachloride histological examination
通讯作者	Tang, L (reprint author), Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China.
产权排序	3
合作状况	其它
英文摘要	Veronica ciliata Fisch. has been traditionally used in Traditional Chinese Medicine prescriptions due to its curative effects for hepatitis, cholecystitis, rheumatism, and urticaria. The present study was focused on investigating the role of ethyl acetate and aqueous extracts of Veronica ciliata Fisch. Furthermore, in vitro antioxidant activity (scavenging of DPPH, ABTS, superoxide, and nitrite radicals; reducing power; beta-carotene bleaching) and the hepatoprotective effect of the ethyl acetate extract by means of CCl4-induced oxidative stress in mice were investigated. The ethyl acetate extract of Veronica ciliata Fisch. displayed more noteworthy in vitro antioxidant activities than the aqueous extract. Moreover, it significantly prevented the increase in serum T-AOC, ALT, AST and ALP level in acute liver damage induced by CCl4, decreased the extent of MDA formation in liver and elevated the activities of SOD and GSH in liver. This activity was found to be comparable to that of bifendate. Histopathological observation of the liver was also performed to further support the evidence from the biochemical analysis. The results indicated that strong antioxidant activities and a significant protective effect against acute hepatotoxicity induced by CCl4 of Veronica ciliata Fisch. were concentrated in the ethyl acetate extract. The results suggested that this activity may be due to free radical-scavenging and antioxidant properties.
学科主题	Chemistry, Organic
收录类别	SCI
语种	英语
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/26679]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Yin, Li,Wei, Lei,Fu, Rao,et al. Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice[J]. MOLECULES,2014,19(6):7223-7236.
APA	Yin, Li.,Wei, Lei.,Fu, Rao.,Ding, Lisheng.,Guo, Yiran.,...&Chen, Fang.(2014).Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice.MOLECULES,19(6),7223-7236.
MLA	Yin, Li,et al."Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice".MOLECULES 19.6(2014):7223-7236.