Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects

	Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects
	Zhang, Zixin 1,2; Tang, Jianxiong 3; Wang, Heran 4; Xia, Qinghua 1,2; Xu, Shanshan 1; Han, Charles C.1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-12-09
卷号	7 期号:48 页码:26400-26404
关键词	electrospinning bicomponent control release intra-abdominal infections antibacterial activity
英文摘要	Implantation of sustained antibacterial system after abdominal surgery could effectively prevent complicated intra-abdominal infection. In this study, a simple blended electrospun membrane made of poly(D,L-lactic-co-glycolide) (PLGA)/poly(dioxanone) (PDO)/Ciprofloxacin hydrochloride (CiH) could easily result in approximately linear drug release profile and sustained antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The addition of PDO changed the stack structure of PLGA, which in turn influenced the fiber swelling and created drug diffusion channels. It could be a good candidate for reducing postoperative infection or be associated with other implant to resist biofilm formation.
收录类别	SCI
语种	英语
公开日期	2016-02-25
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29500]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Joint Lab Polymer Sci & Mat, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Fudan Univ, Huadong Hosp, Shanghai 200040, Peoples R China 4.Minist Sci & Technol, Torch High Technol Ind Dev Ctr, Beijing 100045, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zixin,Tang, Jianxiong,Wang, Heran,et al. Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(48):26400-26404.
APA	Zhang, Zixin,Tang, Jianxiong,Wang, Heran,Xia, Qinghua,Xu, Shanshan,&Han, Charles C..(2015).Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects.ACS APPLIED MATERIALS & INTERFACES,7(48),26400-26404.
MLA	Zhang, Zixin,et al."Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects".ACS APPLIED MATERIALS & INTERFACES 7.48(2015):26400-26404.