Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

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	Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice
	Singh, Vishal 1; Chassaing, Benoit 2; Zhang, Limin 3,4,5,6; Yeoh, Beng San 1; Xiao, Xia 1; Kumar, Manish 1; Baker, Mark T.2; Cai, Jingwei 3; Walker, Rachel 1; Borkowski, Kamil 1
刊名	CELL METABOLISM
	2015-12-01
卷号	22 期号:6 页码:983-996
英文摘要	The gut microbiota plays a key role in host metabolism. Toll-like receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5-deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevated neutral lipids with a compositional increase of oleate [C18:1 (n9)] relative to wild-type littermates. Increased oleate contribution to hepatic lipids and liver SCD1 expression were both microbiota dependent. Analysis of short-chain fatty acids (SCFAs) and C-13-acetate label incorporation revealed elevated SCFA in ceca and hepatic portal blood and increased liver de novo lipogenesis in T5KO mice. Dietary SCFAs further aggravated metabolic syndrome in T5KO mice. Deletion of hepatic SCD1 not only prevented hepatic neutral lipid oleate enrichment but also ameliorated metabolic syndrome in T5KO mice. Collectively, these results underscore the key role of the gut microbiota-liver axis in the pathogenesis of metabolic diseases.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Cell Biology ; Endocrinology & Metabolism
研究领域[WOS]	Cell Biology ; Endocrinology & Metabolism
关键词[WOS]	CHAIN FATTY-ACIDS ; INDUCED INSULIN-RESISTANCE ; DIET-INDUCED OBESITY ; GUT MICROBIOTA ; INFLAMMATORY RESPONSES ; RECEPTOR GPR43 ; HOST ENERGY ; ESTERS ; LIPIDS ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000365993100007
公开日期	2016-01-19
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9080]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA 2.Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA 3.Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA 4.Chinese Acad Sci, Wuhan, Peoples R China 5.State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 6.Natl Ctr Magnet Resonance, Wuhan, Peoples R China 7.Penn State Univ, Dept Anim Sci, University Pk, PA 16802 USA 8.Georgia Regents Univ, Biochem & Mol Biol, Augusta, GA 30912 USA 9.Univ Wisconsin, Dept Biochem & Nutr Sci, Madison, WI 53706 USA 10.Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, Toledo, OH 43614 USA
推荐引用方式 GB/T 7714	Singh, Vishal,Chassaing, Benoit,Zhang, Limin,et al. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice[J]. CELL METABOLISM,2015,22(6):983-996.
APA	Singh, Vishal.,Chassaing, Benoit.,Zhang, Limin.,Yeoh, Beng San.,Xiao, Xia.,...&Vijay-Kumar, Matam.(2015).Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.CELL METABOLISM,22(6),983-996.
MLA	Singh, Vishal,et al."Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice".CELL METABOLISM 22.6(2015):983-996.