Kinetics of Receptor-Ligand Interactions in Immune Responses

CORC > 力学研究所 > 中国科学院力学研究所 > 力学所知识产出(1956-2008)

	Kinetics of Receptor-Ligand Interactions in Immune Responses
	Long M(龙勉); Lv SQ(吕守芹); Sun GY(孙淦云)
刊名	CELLULAR & MOLECULAR IMMUNOLOGY
	2006
通讯作者邮箱	mlong@imech.ac.cn
卷号	3 期号:2 页码:79-86
关键词	kinetics force receptor-ligand bond cell adhesion
ISSN号	1672-7681
通讯作者	Long, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China.
产权排序	[Long, Mian; Lu, Shouqin; Sun, Ganyun] Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China; [Long, Mian; Lu, Shouqin; Sun, Ganyun] Chinese Acad Sci, Ctr Biomech & Bioengn, Inst Mech, Beijing 100080, Peoples R China
中文摘要	Receptor-ligand interactions in blood flow are crucial to initiate the biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesions, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., the two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in immune systems, 2D kinetics and its regulations have less been understood, since no theoretical framework and experimental assays have been established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesions mediated by interacting receptors and ligands. Here we provided the overview of current progresses in 2D bindings and regulations. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations, were discussed.
类目[WOS]	Immunology
研究领域[WOS]	Immunology
收录类别	SCI
语种	英语
WOS记录号	WOS:000208926000001
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/58455]
专题	力学研究所_力学所知识产出(1956-2008)
推荐引用方式 GB/T 7714	Long M,Lv SQ,Sun GY. Kinetics of Receptor-Ligand Interactions in Immune Responses[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2006,3(2):79-86.
APA	龙勉,吕守芹,&孙淦云.(2006).Kinetics of Receptor-Ligand Interactions in Immune Responses.CELLULAR & MOLECULAR IMMUNOLOGY,3(2),79-86.
MLA	龙勉,et al."Kinetics of Receptor-Ligand Interactions in Immune Responses".CELLULAR & MOLECULAR IMMUNOLOGY 3.2(2006):79-86.