Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method | |
Zhong, Jianghong; Tian, Jie![]() | |
刊名 | ANNALS OF BIOMEDICAL ENGINEERING
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2011-06-01 | |
卷号 | 39期号:6页码:1728-1735 |
关键词 | Cerenkov Mathematical model Light propagation in tissues Tomography Molecular imaging |
英文摘要 | Generation of an accurate Cerenkov luminescence imaging model is a current issue of nuclear tomography with optical techniques. The article takes a pro-active approach toward whole-body Cerenkov luminescence tomography. The finite element framework employs the equation of radiative transfer via the third-order simplified spherical harmonics approximation to model Cerenkov photon propagation in a small animal. After this forward model is performed on a digital mouse with optical property heterogeneity and compared with the Monte Carlo method, we investigated the whole body reconstruction algorithm along a regularization path via coordinate descent. The endpoint of the follow-up study is the in vivo application, which provides three-dimensional biodistribution of the radiotracer uptake in the mouse from measured partial boundary currents. The combination of the forward and inverse model with elastic-net penalties is not only validated by numerical simulation, but it also effectively demonstrates in vivo imaging in small animals. Our exact reconstruction method enables optical molecular imaging to best utilize Cerenkov radiation emission from the decay of medical isotopes in tissues. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Engineering, Biomedical |
研究领域[WOS] | Engineering |
关键词[WOS] | SPHERICAL-HARMONICS APPROXIMATION ; POSITRON-EMITTING RADIOTRACERS ; BIOLUMINESCENCE TOMOGRAPHY ; RADIATION ; MODELS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000290724900012 |
公开日期 | 2015-12-24 |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/9753] ![]() |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
作者单位 | Chinese Acad Sci, Med Image Proc Grp, Inst Automat, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Zhong, Jianghong,Tian, Jie,Yang, Xin,et al. Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method[J]. ANNALS OF BIOMEDICAL ENGINEERING,2011,39(6):1728-1735. |
APA | Zhong, Jianghong,Tian, Jie,Yang, Xin,&Qin, Chenghu.(2011).Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method.ANNALS OF BIOMEDICAL ENGINEERING,39(6),1728-1735. |
MLA | Zhong, Jianghong,et al."Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method".ANNALS OF BIOMEDICAL ENGINEERING 39.6(2011):1728-1735. |
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