The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking

	The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking
	Li, Jin1,2 ; Cui, Yue1,2 ; Wu, Karen 3; Liu, Bing1,2 ; Zhang, Yun 4; Wang, Chao 4; Jiang, Tianzi1,2,4,5
刊名	NEUROIMAGE
	2015-08-15
卷号	117 页码:184-190
关键词	Novelty seeking Surface area Cortical thickness Insula DBH
英文摘要	Novelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine-NS relationship. Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure. (C) 2015 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	DOPAMINE-BETA-HYDROXYLASE ; HUMAN CEREBRAL-CORTEX ; OBSESSIVE-COMPULSIVE DISORDER ; VOXEL-BASED MORPHOMETRY ; PERSONALITY-TRAITS ; INDIVIDUAL-DIFFERENCES ; TYROSINE-HYDROXYLASE ; PARKINSONS-DISEASE ; CIGARETTE-SMOKING ; HARM AVOIDANCE
收录类别	SCI
语种	英语
WOS记录号	WOS:000358045100017
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/8869]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Li, Jin,Cui, Yue,Wu, Karen,et al. The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking[J]. NEUROIMAGE,2015,117:184-190.
APA	Li, Jin.,Cui, Yue.,Wu, Karen.,Liu, Bing.,Zhang, Yun.,...&Jiang, Tianzi.(2015).The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking.NEUROIMAGE,117,184-190.
MLA	Li, Jin,et al."The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking".NEUROIMAGE 117(2015):184-190.