Terahertz Time-Domain Spectroscopy and Quantitative Analysis of Metal Gluconates

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	Terahertz Time-Domain Spectroscopy and Quantitative Analysis of Metal Gluconates
	Li, SX; Yang, JQ; Zhao, HW; Yang, N; Jing, DD; Zhang, JB; Li, QN; Han, JG
刊名	APPLIED SPECTROSCOPY
	2015
卷号	69 期号:1 页码:52—57
关键词	D-GLUCOSE MONOHYDRATE ABSORPTION-SPECTRA SACCHARIDES POLYMORPHS COMPLEXES SODIUM MODES ACID
英文摘要	A series of metal gluconates (Na+, K+, Mg2+, Ca2+, Fe2+, Cu2+, and Zn2+) were investigated by terahertz (THz) time-domain spectroscopy. The absorption coefficients and refractive indices of the samples were obtained in the frequency range of 0.5-2.6 THz. The gluconates showed distinct THz characteristic fingerprints, and the dissimilarities reflect their different structures, hydrogen-bond networks, and molecular interactions. In addition, some common features were observed among these gluconates, and the similarities probably come from the similar carbohydrate anion group. The X-ray powder diffraction measurements of these metal gluconates were performed, and the copper(II) gluconate was found to be amorphous, corresponding to the monotonic increase feature in the THz absorption spectrum. The results suggest that THz spectroscopy is sensitive to molecular structure and physical form. Binary and ternary mixtures of different gluconates were quantitatively analyzed based on the Beer-Lambert law. A chemical map of a tablet containing calcium D-gluconate monohydrate and a-lactose in the polyethylene host was obtained by THz imaging. The study shows that THz technology is a useful tool in pharmaceutical research and quality control applications.
收录类别	SCI
语种	英语
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/24593]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Li, SX,Yang, JQ,Zhao, HW,et al. Terahertz Time-Domain Spectroscopy and Quantitative Analysis of Metal Gluconates[J]. APPLIED SPECTROSCOPY,2015,69(1):52—57.
APA	Li, SX.,Yang, JQ.,Zhao, HW.,Yang, N.,Jing, DD.,...&Han, JG.(2015).Terahertz Time-Domain Spectroscopy and Quantitative Analysis of Metal Gluconates.APPLIED SPECTROSCOPY,69(1),52—57.
MLA	Li, SX,et al."Terahertz Time-Domain Spectroscopy and Quantitative Analysis of Metal Gluconates".APPLIED SPECTROSCOPY 69.1(2015):52—57.