Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy | |
Wang, Fei1,2,3; Liu, Pei1,2,3; Sun, Lin4; Li, Cuncheng4; Petrenko, Valery A.5; Liu, Aihua1,2,3 | |
刊名 | SCIENTIFIC REPORTS
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2014-10-28 | |
卷号 | 4期号:1页码:1 |
英文摘要 | Nanomaterials with near-infrared (NIR) absorption have been widely studied in cancer detection and photothermal therapy (PTT), while it remains a great challenge in targeting tumor efficiently with minimal side effects. Herein we report a novel multifunctional phage-mimetic nanostructure, which was prepared by layer-by-layer self-assembly of Au@Ag heterogenous nanorods (NRs) with rhodamine 6G, and specific pVIII fusion proteins. Au@Ag NRs, first being applied for PTT, exhibited excellent stability, cost-effectivity, biocompatibility and tunable NIR absorption. The fusion proteins were isolated from phage DDAGNRQP specifically selected from f8/8 landscape phage library against colorectal cancer cells in a high-throughput way. Considering the definite charge distribution and low molecular weight, phage fusion proteins were assembled on the negatively charged NR core by electrostatic interactions, exposing the N-terminus fused with DDAGNRQP peptide on the surface. The fluorescent images showed that assembled phage fusion proteins can direct the nanostructure into cancer cells. The nanostructure was more efficient than gold nanorods and silver nanotriangle-based photothermal agents and was capable of specifically ablating SW620 cells after 10 min illumination with an 808 nm laser in the light intensity of 4 W/cm(2). The prepared nanostructure would become an ideal reagent for simutaneously targeted optical imaging and PTT of tumor. |
WOS标题词 | Science & Technology |
类目[WOS] | Multidisciplinary Sciences |
研究领域[WOS] | Science & Technology - Other Topics |
关键词[WOS] | BREAST-CANCER CELLS ; GOLD NANORODS ; SILVER NANOPARTICLES ; FILAMENTOUS PHAGE ; LANDSCAPE PHAGE ; COAT PROTEIN ; CARBON NANOTUBES ; DISPLAY LIBRARY ; SURFACE ; DELIVERY |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000343981300001 |
内容类型 | 期刊论文 |
源URL | [http://ir.qibebt.ac.cn/handle/337004/6160] ![]() |
专题 | 青岛生物能源与过程研究所_生物传感技术团队 |
作者单位 | 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Lab Biosensing, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Key Lab Biofuels, Qingdao 266101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Jinan, Shandong Univ, Sch Chem & Chem Engn, Key Lab Chem Sensing & Anal, Jinan 250022, Peoples R China 5.Auburn Univ, Dept Pathobiol, Auburn, AL 36849 USA |
推荐引用方式 GB/T 7714 | Wang, Fei,Liu, Pei,Sun, Lin,et al. Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy[J]. SCIENTIFIC REPORTS,2014,4(1):1. |
APA | Wang, Fei,Liu, Pei,Sun, Lin,Li, Cuncheng,Petrenko, Valery A.,&Liu, Aihua.(2014).Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy.SCIENTIFIC REPORTS,4(1),1. |
MLA | Wang, Fei,et al."Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy".SCIENTIFIC REPORTS 4.1(2014):1. |
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