Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B

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	Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B
	Qin, Jianchun 1; Su, Hua 2; Zhang, Yamei 1; Gao, Jinming 3; Zhu, Lin 1; Wu, Xian 1; Pan, Hongyu 1; Li, Xiang 1,4
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2010-12-01
卷号	20 期号:23 页码:7152-7154
关键词	Brominated metabolites Laurencia similis Protein tyrosine phosphatase 1B
英文摘要	Five new highly brominated metabolites, 3',5',6',6-tetrabromo-2,4-dimethyldiphenyl ether (1), 1,2,5-tribromo-3-bromoamino-7-bromomethylnaphthalene (2), 2,5,8-tribromo-3-bromoamino-7-bromomethylnaphthalene (3), 2,5,6-tribromo-3-bromoamino-7-bromomethylnaphthalene (4) and 2',5',6',5, 6-pentabromo-3',4',3,4-tetramethoxybenzo-phenone (5) were isolated from the red alga Laurencia similis. Their structures were elucidated by spectroscopic methods including one-and two-dimensional NMR as well as HREIMS analysis. Compounds 1 and 5 showed strong inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC(50) of 2.97 and 2.66 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	ARISTOLANE SESQUITERPENES ; RHODOMELACEAE
收录类别	SCI
语种	英语
WOS记录号	WOS:000283801400059
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/6533]
专题	青岛生物能源与过程研究所_人力资源部
作者单位	1.Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China 3.NW A&F Univ, Nat Med Chem Res Ctr, Coll Sci, Yangling 712100, Peoples R China 4.Agr & Agri Food Canada, Saskatoon, SK S7N 0X2, Canada
推荐引用方式 GB/T 7714	Qin, Jianchun,Su, Hua,Zhang, Yamei,et al. Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(23):7152-7154.
APA	Qin, Jianchun.,Su, Hua.,Zhang, Yamei.,Gao, Jinming.,Zhu, Lin.,...&Li, Xiang.(2010).Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(23),7152-7154.
MLA	Qin, Jianchun,et al."Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.23(2010):7152-7154.