Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis

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	Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis
	Du, Y.1,2 ; Gao, L.1,2 ; Zhang, K.1 ; Wang, J.1
刊名	GENETICS AND MOLECULAR RESEARCH
	2015
卷号	14 期号:4 页码:13236-13246
关键词	rs1800796 Interleukin 6 Cancer risk Meta-analysis
ISSN号	1676-5680
英文摘要	The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out to determine whether this SNP is associated with cancer risk. However, the results are inconsistent due to small sample sizes of individual studies and limited statistical power. Therefore, to evaluate the overall effect on all investigated cancer types, we conducted a meta-analysis by combining all available studies. Nineteen eligible case-control studies including 23,030 subjects (9,985 cases and 13,045 controls) were included for this meta-analysis. Our study demonstrates that rs1800796 is significantly associated with cancer risk in three genetic models (allele G vs allele C, pooled OR = 1.182, P = 0.009; CG + GG vs CC, pooled OR = 1.333, P = 0.006; CG vs CC, pooled OR = 1.323, P = 0.007). Our meta-analysis suggests that Meta-analysis of IL6 polymorphism and cancer risk.
收录类别	SCI
语种	英语
WOS记录号	WOS:000364582000020
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/15318]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Du, Y.,Gao, L.,Zhang, K.,et al. Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(4):13236-13246.
APA	Du, Y.,Gao, L.,Zhang, K.,&Wang, J..(2015).Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis.GENETICS AND MOLECULAR RESEARCH,14(4),13236-13246.
MLA	Du, Y.,et al."Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis".GENETICS AND MOLECULAR RESEARCH 14.4(2015):13236-13246.